- Monday, Nov 17th, 2025
| TITLE | An Update on Various Penetration Techniques for Drug Delivery through Nails |
|---|---|
| ABSTRACT | Fungal infections relating to the nails similar as onychomycosis, nail psoriasis involve the treatment with the aid of the oral remedy with the antifungal class of the medicines. Despite it’s use the oral remedy was associated with the systemic side goods similar as hepatotoxicity and problems relating to the medicine’s bioavailability. thus, transungual medicine delivery system came but held its own limitations and challenges. Cross linked keratin liaison of the nail plate conducting the expansive cling is responsible for hardness of the nail plate. To exclude the problems associated a number of mechanical and chemical approaches were deeply studied and analysed. Anyhow of employing the chemicals like penetration enhancers enhancing the flux across nails and weakening the integrity of nails, the topical permeability was still constricted due to its hedge parcels. new nail plate made up of mortal hair keratin was also delved as an indispensable model for studying flux across nail. Novel nail plate developed with the aid of keratin derived from human hair was also analysed as the reference model to study flux across nails. The best vehicle for antifungals is nail lacquers. Numerous studies are being conducted on the development of innovative penetration enhancers, water-based nail lacquers, and nail varnish containing antimycotic agents. Another treatment option for onychomycosis is patch-based administration, which consists of an occlusive backing layer and a pressure-sensitive adhesive matrix layer containing the active drug. In order to cure different skin infections, efforts are made to create devices that use a laser or germicidal light to improve penetration through the nail. Newer technologies show great promise and produce positive outcomes. |
| AUTHOR | Ruhit Ashraf, Hema Rani, Gursimran Singh Assistant Professor, S. Lal Singh Memorial College of Pharmacy, Desh Bhagat University, Punjab, India Associate Professor, S. Lal Singh Memorial College of Pharmacy, Desh Bhagat University, Punjab, India Pursuing B. Pharmacy, S. Lal Singh Memorial College of Pharmacy, Desh Bhagat University, Punjab, India |
| PUBLICATION DATE | 2025-10-10 |
| VOLUME | 12 |
| DOI | DOI:10.15680/IJARETY.2025.1205011 |
| 11_An Update on Various Penetration Techniques for Drug Delivery through Nails.pdf | |
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